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Issue 22, 2009
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The design, synthesis and evaluation of hypoxia-activated pro-oligonucleotides

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Abstract

Hypoxia-activated pro-oligonucleotides were synthesized through the commercial phosphoramidite method, and could be readily cleaved to form normal oligos with good hypoxia selectivity in vitro under the effect of reductases, as well as in tumor cell extract.

Graphical abstract: The design, synthesis and evaluation of hypoxia-activated pro-oligonucleotides

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Publication details

The article was received on 17 Feb 2009, accepted on 27 Mar 2009 and first published on 23 Apr 2009


Article type: Communication
DOI: 10.1039/B903331A
Citation: Chem. Commun., 2009,0, 3216-3218
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    The design, synthesis and evaluation of hypoxia-activated pro-oligonucleotides

    N. Zhang, C. Tan, P. Cai, P. Zhang, Y. Zhao and Y. Jiang, Chem. Commun., 2009, 0, 3216
    DOI: 10.1039/B903331A

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