Targeting exofacial protein thiols with GdIII complexes. An efficient procedure for MRI cell labelling

Giuseppe Digilio; Valeria Catanzaro; Franco Fedeli; Eliana Gianolio; Valeria Menchise; Roberta Napolitano; Concetta Gringeri; Silvio Aime

doi:10.1039/B820593K

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Targeting exofacial protein thiols with Gd^III complexes. An efficient procedure for MRI cell labelling†

Giuseppe Digilio,*^a Valeria Catanzaro,^b Franco Fedeli,^b Eliana Gianolio,^b Valeria Menchise,^c Roberta Napolitano,^b Concetta Gringeri^a and Silvio Aime^b

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* Corresponding authors

^a Department of Environmental and Life Sciences, University of Eastern Piedmont “A. Avogadro”, Via Bellni 25G, 15100 Alessandria, Italy
E-mail: giuseppe.digilio@mfn.unipmn.it
Fax: +39 011 6706487
Tel: +39 0131 360358

^b Department of Chemistry IFM & Center for Molecular Imaging, University of Turin, Via Nizza 52, 10125 Torino, Italy

^c Istituto Biostrutture e Biommagini – CNR, Via Mezzocannone 16, 80143 Napoli, Italy

Abstract

Cells display on the outer surface of the plasma membrane a large number of protein thiols that can be reversibly labelled with suitably designed Gd^III-based contrast agents for cell tracking by MRI.

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Supplementary files

Determination of Gd^III content in cells PDF (285K)

Article information

DOI: https://doi.org/10.1039/B820593K
Article type: Communication
Submitted: 20 Nov 2008
Accepted: 08 Jan 2009
First published: 26 Jan 2009

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Chem. Commun., 2009, 893-895

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Targeting exofacial protein thiols with Gd^III complexes. An efficient procedure for MRI cell labelling

G. Digilio, V. Catanzaro, F. Fedeli, E. Gianolio, V. Menchise, R. Napolitano, C. Gringeri and S. Aime, Chem. Commun., 2009, 893 DOI: 10.1039/B820593K

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Chemical Communications