Novel defluorinative alkylation of trifluoroacetaldehyde N,O-acetal derivatives and its application to multi-component reaction

Abstract

The reaction of trifluoroacetaldehyde N,O-acetal derivatives with 2 molar equivalents of alkyllithium reagents proceeded viaβ-elimination of fluoride followed by alkyl transfer from excess alkyllithium to the generated keteneN,O-acetal intermediate at the β-carbon of fluorine groups.