Issue 47, 2008

Highly efficient copper-catalyzed cascade synthesis of quinazoline and quinazolinone derivatives

Abstract

We have developed a general and highly efficient copper-catalyzed method for synthesis of quinazoline and quinazolinone derivatives, the target products were obtained in good to excellent yields via cascade reactions of amidine hydrochlorides with substituted 2-halobenzaldehydes, 2-halophenylketones, or methyl 2-halobenzoates, and the method is of simple, economical and practical advantages.

Graphical abstract: Highly efficient copper-catalyzed cascade synthesis of quinazoline and quinazolinone derivatives

Supplementary files

Article information

Article type
Communication
Submitted
12 Aug 2008
Accepted
22 Sep 2008
First published
24 Oct 2008

Chem. Commun., 2008, 6333-6335

Highly efficient copper-catalyzed cascade synthesis of quinazoline and quinazolinone derivatives

C. Huang, Y. Fu, H. Fu, Y. Jiang and Y. Zhao, Chem. Commun., 2008, 6333 DOI: 10.1039/B814011A

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