Vanadium–vitamin B12 bioconjugates as potential therapeutics for treating diabetes

Riya Mukherjee; Edward G. Donnay; Michal A. Radomski; Catherine Miller; Duane A. Redfern; Arne Gericke; Derek S. Damron; Nicola E. Brasch

doi:10.1039/B806598E

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Vanadium–vitamin B₁₂ bioconjugates as potential therapeutics for treating diabetes†

Riya Mukherjee,^a Edward G. Donnay,^a Michal A. Radomski,^a Catherine Miller,^b Duane A. Redfern,^a Arne Gericke,^a Derek S. Damron^c and Nicola E. Brasch*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Kent State University, Kent, USA
E-mail: nbrasch@kent.edu

^b Department of Chemistry, John Carroll University, Cleveland Heights, USA

^c Department of Biological Sciences, Kent State University, Kent, USA

Abstract

The synthesis and blood glucose lowering properties of the first vanadium–vitamin B₁₂ bioconjugates are reported.

Download options Please wait...

Supplementary files

Synthesis, purification, ¹H NMR and UV-Vis spectra for 1, ¹H and ⁵¹V NMR data at varying ratios of 1 to NaVO ₃, experimental details on the attempted purification of 2 and 3, FTIR experiments and the determination of diffusion coefficients PDF (615K)

Article information

DOI: https://doi.org/10.1039/B806598E
Article type: Communication
Submitted: 18 Apr 2008
Accepted: 01 May 2008
First published: 20 Jun 2008

Download Citation

Chem. Commun., 2008, 3783-3785

Permissions

Request permissions

Vanadium–vitamin B₁₂ bioconjugates as potential therapeutics for treating diabetes

R. Mukherjee, E. G. Donnay, M. A. Radomski, C. Miller, D. A. Redfern, A. Gericke, D. S. Damron and N. E. Brasch, Chem. Commun., 2008, 3783 DOI: 10.1039/B806598E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications