Issue 25, 2008

A potential role for protein tyrosine phosphatase inhibition by a RuIII–edta complex (edta = ethylenediaminetetraacetate) in its biological activity

Abstract

[RuIII(edta)(OH2/OH)]1−/2− (edta = ethylenediaminetetraacetate) inhibits protein tyrosine phosphatase (PTP) at physiological pH values in a mechanism that involves binding of the Cys residue of the catalytic domain of the enzyme and similar interactions may be important in the anti-cancer properties of the active forms of many Ru pro-drugs.

Graphical abstract: A potential role for protein tyrosine phosphatase inhibition by a RuIII–edta complex (edta = ethylenediaminetetraacetate) in its biological activity

Article information

Article type
Communication
Submitted
26 Feb 2008
Accepted
03 Apr 2008
First published
28 May 2008

Chem. Commun., 2008, 2864-2866

A potential role for protein tyrosine phosphatase inhibition by a RuIII–edta complex (edta = ethylenediaminetetraacetate) in its biological activity

D. Chatterjee, A. Mitra, A. Levina and P. A. Lay, Chem. Commun., 2008, 2864 DOI: 10.1039/B803261K

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