Issue 25, 2008
From the journal:

Chemical Communications

8-Amino guanine accelerates tetramolecular G-quadruplex formation†‡

Julien Gros,a   Anna Aviñó,b   Jaime Lopez de la Osa,c   Carlos González,c   Laurent Lacroix,a   Alberto Pérez,d   Modesto Orozco,de   Ramon Eritja*b  and  Jean-Louis Mergny*a  

* Corresponding authors

a Muséum National d’Histoire Naturelle (MNHN) USM 503, INSERM U565, CRNS UMR 5153; 43 rue Cuvier CP26, Paris Cedex 05, France
E-mail: mergny@mnhn.fr
Fax: +33 1 40 79 37 05
Tel: +33 1 40 79 36 89

b IRB Barcelona, CIBER-BBN, CSIC Josep Samitier 1-5, Barcelona, Spain
E-mail: recgma@cid.csic.es
Fax: +34-93-2045904
Tel: +34-93-4039942

c Instituto de Química Física Rocasolano, CSIC, C/Serrano, 119, Madrid, Spain

d Joint IRB-BSC program on Computational Biology, Institut de Recerca Biomèdica, Parc Científic de Barcelona, Josep Samitier 1-5, 08028 Barcelona, Spain, and Barcelona Supercomputing Center, Jordi Girona 29, Barcelona, Spain

e Departament de Bioquímica, Facultat de Biologia, Universitat de Barcelona, Avgda Diagonal 647, Barcelona, Spain

Abstract

We demonstrate here that 8-amino guanine (R) strongly accelerates quadruplex formation, which makes this nucleobase the most attractive replacement for guanine in the context of tetramolecular parallel quadruplexes.

Graphical abstract: 8-Amino guanine accelerates tetramolecular G-quadruplex formation

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Article information

DOI
https://doi.org/10.1039/B801221K
Article type
Communication
Submitted
22 Jan 2008
Accepted
11 Mar 2008
First published
15 Apr 2008

Chem. Commun., 2008, 2926-2928

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8-Amino guanine accelerates tetramolecular G-quadruplex formation

J. Gros, A. Aviñó, J. Lopez de la Osa, C. González, L. Lacroix, A. Pérez, M. Orozco, R. Eritja and J. Mergny, Chem. Commun., 2008, 2926 DOI: 10.1039/B801221K

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