Issue 12, 2008
From the journal:

Chemical Communications

One-step synthesis of polysubstituted benzene derivatives by multi-component cyclization of α-bromoacetate, malononitrile and aromatic aldehydes†

Chao Guo Yan,*a   Xiao Kai Song,a   Qi Fang Wang,a   Jing Sun,a   Ulrich Siemeling*b  and  Clemens Bruhnb  

* Corresponding authors

a College of Chemistry & Chemical Engineering Yangzhou University, Yangzhou 225002, China

b Institute of Chemistry University of Kassel Heinrich-Plett-Strasse 40, D-34132 Kassel
E-mail: cgyan@yzu.edu.cn

Abstract

Polysubstituted benzene derivatives with an unprecedented substitution pattern are produced in a novel one-pot multi-component cyclization reaction from pyridine, ethyl α-bromoacetate, malononitrile and aromatic aldehyde in refluxing acetonitrile.

Graphical abstract: One-step synthesis of polysubstituted benzene derivatives by multi-component cyclization of α-bromoacetate, malononitrile and aromatic aldehydes

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Article information

DOI
https://doi.org/10.1039/B718171J
Article type
Communication
Submitted
23 Nov 2007
Accepted
08 Jan 2008
First published
25 Jan 2008

Chem. Commun., 2008, 1440-1442

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One-step synthesis of polysubstituted benzene derivatives by multi-component cyclization of α-bromoacetate, malononitrile and aromatic aldehydes

C. G. Yan, X. K. Song, Q. F. Wang, J. Sun, U. Siemeling and C. Bruhn, Chem. Commun., 2008, 1440 DOI: 10.1039/B718171J

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