Enhanced radical-scavenging activity of naturally-oriented artepillin C derivatives

Sushma Manda; Ikuo Nakanishi; Kei Ohkubo; Yoshihiro Uto; Tomonori Kawashima; Hitoshi Hori; Kiyoshi Fukuhara; Haruhiro Okuda; Toshihiko Ozawa; Nobuo Ikota; Shunichi Fukuzumi; Kazunori Anzai

doi:10.1039/B715973K

Enhanced radical-scavenging activity of naturally-oriented artepillin C derivatives†

Sushma Manda,^a Ikuo Nakanishi,*^ab Kei Ohkubo,^b Yoshihiro Uto,^c Tomonori Kawashima,^b Hitoshi Hori,^c Kiyoshi Fukuhara,^d Haruhiro Okuda,^d Toshihiko Ozawa,^ae Nobuo Ikota,^f Shunichi Fukuzumi*^b and Kazunori Anzai*^a

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* Corresponding authors

^a Radiation Modifier Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences (NIRS), Inage-ku, Chiba 263-8555, Japan
E-mail: nakanis@nirs.go.jp
Fax: +81-43-255-6819
Tel: +81-43-206-3131

^b Department of Material and Life Science, Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency (JST), Suita, Osaka 565-0871, Japan

^c Faculty of Engineering, The University of Tokushima, Tokushima 770-8506, Japan

^d Division of Organic Chemistry, National Institute of Health Sciences (NIHS), Setagaya-ku, Tokyo 158-8501, Japan

^e Department of Health Pharmacy, Yokohama College of Pharmacy, Yokohama 245-0066, Japan

^f School of Pharmacy, Shujitsu University, Okayama 703-8516, Japan

Abstract

More than two-fold augmentation in the radical-scavenging activity of artepillin C could be achieved via altering the O–H bond dissociation enthalpy of artepillin C by means of structural modifications.

Chemical Communications

Enhanced radical-scavenging activity of naturally-oriented artepillin C derivatives†

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Enhanced radical-scavenging activity of naturally-oriented artepillin C derivatives

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