Issue 1, 2008

Questioning the paradigm of metal complex promoted phosphodiester hydrolysis: [Mo7O24]6− polyoxometalate cluster as an unlikely catalyst for the hydrolysis of a DNA model substrate

Abstract

The first example of a phosphodiester bond cleavage promoted by a highly negatively charged polyoxometalate cluster has been discovered: the hydrolysis of the phosphodiester bond in a DNA model substrate bis(p-nitrophenyl)phosphate (BNPP) is promoted by the heptamolybdate anion [Mo7O24]6− with rates which represent an acceleration of nearly four orders of magnitude compared to the uncatalyzed cleavage.

Graphical abstract: Questioning the paradigm of metal complex promoted phosphodiester hydrolysis: [Mo7O24]6− polyoxometalate cluster as an unlikely catalyst for the hydrolysis of a DNA model substrate

Supplementary files

Article information

Article type
Communication
Submitted
26 Sep 2007
Accepted
08 Nov 2007
First published
16 Nov 2007

Chem. Commun., 2008, 85-87

Questioning the paradigm of metal complex promoted phosphodiester hydrolysis: [Mo7O24]6− polyoxometalate cluster as an unlikely catalyst for the hydrolysis of a DNA model substrate

E. Cartuyvels, G. Absillis and T. N. Parac-Vogt, Chem. Commun., 2008, 85 DOI: 10.1039/B714860G

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