Issue 33, 2007
From the journal:

Chemical Communications

Following a protein kinase activity using a field-effect transistor device

Ronit Freeman,a   Ron Gilla  and  Itamar Willner*a  

* Corresponding authors

a Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
E-mail: willnea@vms.huji.ac.il
Fax: 972-2-6527715
Tel: 972-2-6585272

Abstract

The specific phosphorylation of a peptide-functionalized ion-sensitive field-effect transistor device by casein kinase II in the presence of ATP enables the electronic readout of the protein kinase activity; treatment of the phosphorylated surface with alkaline phosphatase results in the regeneration of the active sensing surface.

Graphical abstract: Following a protein kinase activity using a field-effect transistor device

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Article information

DOI
https://doi.org/10.1039/B707677K
Article type
Communication
Submitted
22 May 2007
Accepted
09 Jul 2007
First published
30 Jul 2007

Chem. Commun., 2007, 3450-3452

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Following a protein kinase activity using a field-effect transistor device

R. Freeman, R. Gill and I. Willner, Chem. Commun., 2007, 3450 DOI: 10.1039/B707677K

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