Synthesis and reactivity of [18F]-N-fluorobenzenesulfonimide

Harriet Teare; Edward G. Robins; Erik Årstad; Sajinder K. Luthra; Véronique Gouverneur

doi:10.1039/B701177F

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Synthesis and reactivity of [¹⁸F]-N-fluorobenzenesulfonimide†

Harriet Teare,^a Edward G. Robins,^b Erik Årstad,^b Sajinder K. Luthra*^b and Véronique Gouverneur*^a

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* Corresponding authors

^a Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK
E-mail: veronique.gouverneur@chem.ox.ac.uk
Fax: 44 1865 275644
Tel: 44 1865 275644

^b Hammersmith Imanet Ltd (part of GE Healthcare), Hammersmith Hospital, Du Cane Road, London, UK

Abstract

A novel [¹⁸F]NF reagent and two novel radiochemical transformations have been developed: [¹⁸F]NFSi has been prepared from sodium dibenzenesulfonimide and reacted in the presence of silyl enol ethers and allylsilanes to deliver labelled fluorinated ketones and allylic fluorides respectively; the radiosynthesis of the fluorinated A ring of vitamin D₃ has also been completed with success.

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Article information

DOI: https://doi.org/10.1039/B701177F
Article type: Communication
Submitted: 25 Jan 2007
Accepted: 23 Feb 2007
First published: 14 Mar 2007

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Chem. Commun., 2007, 2330-2332

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Synthesis and reactivity of [¹⁸F]-N-fluorobenzenesulfonimide

H. Teare, E. G. Robins, E. Årstad, S. K. Luthra and V. Gouverneur, Chem. Commun., 2007, 2330 DOI: 10.1039/B701177F

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