Issue 18, 2007
From the journal:

Chemical Communications

Palladium-catalyzed conjugate reduction of enones into α,β-dideuterioketones with hexamethyldisilane and deuterium oxide†

Hidehito Otsuka,a   Eiji Shirakawa*a  and  Tamio Hayashi*a  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Japan
E-mail: shirakawa@kuchem.kyoto-u.ac.jp
Fax: +81 75 753 3988

Abstract

Conjugated enones are reduced by readily available Me3SiSiMe3 and D2O in the presence of a catalytic amount of [PdCl(η3-C3H5)]2–PPh3 to give α,β-dideuterioketones.

Graphical abstract: Palladium-catalyzed conjugate reduction of enones into α,β-dideuterioketones with hexamethyldisilane and deuterium oxide

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Article information

DOI
https://doi.org/10.1039/B618107D
Article type
Communication
Submitted
12 Dec 2006
Accepted
16 Jan 2007
First published
08 Feb 2007

Chem. Commun., 2007, 1819-1821

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Palladium-catalyzed conjugate reduction of enones into α,β-dideuterioketones with hexamethyldisilane and deuterium oxide

H. Otsuka, E. Shirakawa and T. Hayashi, Chem. Commun., 2007, 1819 DOI: 10.1039/B618107D

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