Issue 4, 2007
From the journal:

Chemical Communications

Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding†

Abid Khan,a   Jon D. Silversides,a   Leigh Madden,b   John Greenmanb  and  Stephen J. Archibald*a  

* Corresponding authors

a Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK
E-mail: s.j.archibald@hull.ac.uk
Fax: +44(0)1482 466410
Tel: +44(0)1482 465488

b Medical Research Laboratory and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK

Abstract

The copper(II) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.

Graphical abstract: Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding

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Article information

DOI
https://doi.org/10.1039/B614557D
Article type
Communication
Submitted
06 Oct 2006
Accepted
15 Nov 2006
First published
04 Dec 2006
This article is Open Access

Chem. Commun., 2007, 416-418

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Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding

A. Khan, J. D. Silversides, L. Madden, J. Greenman and S. J. Archibald, Chem. Commun., 2007, 416 DOI: 10.1039/B614557D

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