Issue 4, 2007
From the journal:

Chemical Communications

One-pot preparation of coenzyme A analogues via an improved chemo-enzymatic synthesis of pre-CoA thioester synthons†

Marianne van Wyka  and  Erick Strauss*a  

* Corresponding authors

a Department of Chemistry, Stellenbosch University, Matieland, South Africa
E-mail: estrauss@sun.ac.za
Fax: +27-21-808-3360

Abstract

Coenzyme A analogues are synthesized in a one-pot preparation by biotransformation of pantothenate thioesters through the simultaneous use of three CoA biosynthetic enzymes, followed by aminolysis.

Graphical abstract: One-pot preparation of coenzyme A analogues via an improved chemo-enzymatic synthesis of pre-CoA thioester synthons

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Article information

DOI
https://doi.org/10.1039/B613527G
Article type
Communication
Submitted
18 Sep 2006
Accepted
24 Oct 2006
First published
14 Nov 2006

Chem. Commun., 2007, 398-400

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One-pot preparation of coenzyme A analogues via an improved chemo-enzymatic synthesis of pre-CoA thioester synthons

M. van Wyk and E. Strauss, Chem. Commun., 2007, 398 DOI: 10.1039/B613527G

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