Issue 48, 2006
From the journal:

Chemical Communications

Sequential one-pot bimetallic Ir(iii)/Pd(0) catalysed mono-/bis-alkylation and spirocyclisation processes of 1,3-dimethylbarbituric acid and allenes†

Christian Löfberg,a   Ronald Grigg,*a   Ann Keep,b   Andrew Derrick,c   Visuvanathar Sridharana  and  Colin Kilnera  

* Corresponding authors

a Molecular Innovation, Diversity and Automated Synthesis (MIDAS) Centre, School of Chemistry, University of Leeds, Leeds, UK
E-mail: r.grigg@leeds.ac.uk
Fax: 0113 343 6530
Tel: 0113 343 6501

b Johnson Matthey, Orchard Road, Royston, Herts, UK

c Pfizer, Ramsgate Road, Sandwich, Kent, UK

Abstract

Microwave assisted indirect functionalization of alcohols with 1,3-dimethylbarbituric acid followed by spirocyclisation employing a sequential one-pot Ir(III)/Pd(0) catalysed process, involving the formation of three new C–C bonds, one spirocyclic ring and one di- or tri-substituted exocyclic alkene, is described.

Graphical abstract: Sequential one-pot bimetallic Ir(iii)/Pd(0) catalysed mono-/bis-alkylation and spirocyclisation processes of 1,3-dimethylbarbituric acid and allenes

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B614098J
Article type
Communication
Submitted
28 Sep 2006
Accepted
27 Oct 2006
First published
15 Nov 2006

Chem. Commun., 2006, 5000-5002

Permissions

Request permissions

Sequential one-pot bimetallic Ir(III)/Pd(0) catalysed mono-/bis-alkylation and spirocyclisation processes of 1,3-dimethylbarbituric acid and allenes

C. Löfberg, R. Grigg, A. Keep, A. Derrick, V. Sridharan and C. Kilner, Chem. Commun., 2006, 5000 DOI: 10.1039/B614098J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements