Issue 48, 2006
From the journal:

Chemical Communications

Detection of a single DNA base-pair mismatch using an anthracene-tagged fluorescent probe†

Nina Moran,a   Dario M. Bassani,*b   Jean-Pierre Desvergne,b   Sonja Keiper,c   Philip A. S. Lowden,d   Joseph S. Vyle*c  and  James H. R. Tucker*a  

* Corresponding authors

a School of Chemistry, University of Birmingham, Edgbaston, Birmingham, UK
E-mail: j.tucker@bham.ac.uk
Fax: +44 (0)12 1414 4403
Tel: +44 (0)12 1414 4422

b Laboratoire de Chimie Organique et Organométallique, Université Bordeaux 1, 351 Crs Libération, Talence, France
E-mail: d.bassani@lcoo.u-bordeaux1.fr
Fax: 33(0) 540 00 6158
Tel: 33(0) 540 00 2827

c School of Chemistry and Chemical Engineering, Queen's University Belfast (QUB), Stranmillis Road, Belfast, UK
E-mail: j.vyle@qub.ac.uk
Fax: +44 (0)28 9097 6524
Tel: +44 (0)28 9097 5485

d School of Biological and Chemical Sciences, Malet Street, Bloomsbury, London, UK

Abstract

A novel anthracene-tagged oligonucleotide can discriminate between a fully-matched DNA target sequence and one with a single mismatching base-pair through a remarkable difference in fluorescence emission intensity upon duplex formation.

Graphical abstract: Detection of a single DNA base-pair mismatch using an anthracene-tagged fluorescent probe

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Article information

DOI
https://doi.org/10.1039/B611650G
Article type
Communication
Submitted
14 Aug 2006
Accepted
23 Oct 2006
First published
06 Nov 2006

Chem. Commun., 2006, 5003-5005

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Detection of a single DNA base-pair mismatch using an anthracene-tagged fluorescent probe

N. Moran, D. M. Bassani, J. Desvergne, S. Keiper, P. A. S. Lowden, J. S. Vyle and J. H. R. Tucker, Chem. Commun., 2006, 5003 DOI: 10.1039/B611650G

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