Issue 40, 2006

A short water-soluble self-assembling peptide forms amyloid-like fibrils

Abstract

A water-soluble tripeptide Val–Ile–Ala (VIA) 1, bearing sequence identity with the C-terminal portion of the Alzheimer Aβ-peptide (Aβ40–42), self-assembles, in crystalline form, to produce an intermolecularly hydrogen bonded supramolecular β-sheet structure which self-associates to form straight, unbranched nanofibrils exhibiting amyloid-like behavior; in contrast, the synthetic tripeptide Ala–Val–Ile (AVI) 2 self-assembles to produce a β-sheet structure that forms branched nanofibrils which do not show any characteristic features of amyloid-like fibrils.

Graphical abstract: A short water-soluble self-assembling peptide forms amyloid-like fibrils

Supplementary files

Article information

Article type
Communication
Submitted
31 May 2006
Accepted
08 Aug 2006
First published
30 Aug 2006

Chem. Commun., 2006, 4230-4232

A short water-soluble self-assembling peptide forms amyloid-like fibrils

S. Ray, A. K. Das, M. G. B. Drew and A. Banerjee, Chem. Commun., 2006, 4230 DOI: 10.1039/B607657B

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