Issue 11, 2006

Synthesis of the bicyclic core of tagetitoxin

Abstract

A synthesis of the 9-oxa-3-thiabicyclo[3.3.1]nonane ring system, which constitutes the core of the RNA polymerase inhibitor tagetitoxin, has been achieved through cyclisation of a thiol onto an electrophilic ketone.

Graphical abstract: Synthesis of the bicyclic core of tagetitoxin

Supplementary files

Article information

Article type
Communication
Submitted
19 Jan 2006
Accepted
31 Jan 2006
First published
14 Feb 2006

Chem. Commun., 2006, 1197-1199

Synthesis of the bicyclic core of tagetitoxin

J. R. H. Plet and M. J. Porter, Chem. Commun., 2006, 1197 DOI: 10.1039/B600819D

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