Issue 22, 2006
From the journal:

Chemical Communications

Carbohydrate triazoles and isoxazoles as inhibitors of galectins-1 and -3†

Denis Giguère,a   Ramesh Patnam,a   Marc-André Bellefleur,a   Christian St-Pierre,b   Sachiko Satob  and  René Roy*a  

* Corresponding authors

a Department of Chemistry, Université du Québec à Montréal, P.O. Box 8888, Succ. Centre-Ville Montreal, Que., Canada
E-mail: roy.rene@uqam.ca
Fax: +1 514 987 4054
Tel: +514 987 3000x2546

b Research Center for Infectious Diseases, Faculty of Medicine, Université Laval, 2705 boul. Laurier, RC-9700 Sainte-Foy, Que., Canada

Abstract

Galactosides and lactosides bearing triazoles or isoxazoles, regiospecifically prepared by [1,3]-dipolar cycloadditions between alkynes, azides or nitrile oxides, provided specific galectin-1 and -3 inhibitors with potencies as low as 20 µM.

Graphical abstract: Carbohydrate triazoles and isoxazoles as inhibitors of galectins-1 and -3

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Article information

DOI
https://doi.org/10.1039/B517529A
Article type
Communication
Submitted
09 Dec 2005
Accepted
28 Feb 2006
First published
16 Mar 2006

Chem. Commun., 2006, 2379-2381

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Carbohydrate triazoles and isoxazoles as inhibitors of galectins-1 and -3

D. Giguère, R. Patnam, M. Bellefleur, C. St-Pierre, S. Sato and R. Roy, Chem. Commun., 2006, 2379 DOI: 10.1039/B517529A

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