Issue 33, 2005

2-Phenallyl as a versatile protecting group for the asymmetric one-pot three-component synthesis of propargylamines

Abstract

2-Phenallyl was found to be a versatile protecting group of primary amines for the asymmetric one-pot three-component synthesis of propargylamines which leads to enantiomeric excess of up to 96%; it can be easily removed with a palladium(0)-catalyzed allylic substitution using 1,3-dimethylbarbituric acid as a nucleophile.

Graphical abstract: 2-Phenallyl as a versatile protecting group for the asymmetric one-pot three-component synthesis of propargylamines

Supplementary files

Article information

Article type
Communication
Submitted
03 Jun 2005
Accepted
05 Jul 2005
First published
26 Jul 2005

Chem. Commun., 2005, 4175-4177

2-Phenallyl as a versatile protecting group for the asymmetric one-pot three-component synthesis of propargylamines

N. Gommermann and P. Knochel, Chem. Commun., 2005, 4175 DOI: 10.1039/B507810E

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