Issue 12, 2005
From the journal:

Chemical Communications

Combining sugar biosynthesis genes for the generation of l- and d-amicetose and formation of two novel antitumor tetracenomycins†

María Pérez,a   Felipe Lombó,a   Lili Zhu,b   Miranda Gibson,b   Alfredo F. Braña,a   Jürgen Rohr,b   José A. Salasa  and  Carmen Méndez*a  

* Corresponding authors

a Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, Oviedo, Spain
E-mail: cmendezf@uniovi.es
Fax: +34-985-103652
Tel: +34-985-103558

b Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA
E-mail: jrohr2@uky.edu
Tel: +1-859-323-5031

Abstract

L- and D-stereoisomers of amicetose were generated by combining sugar biosynthesis genes from four different antibiotic gene clusters and both sugars were transferred to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase.

Graphical abstract: Combining sugar biosynthesis genes for the generation of l- and d-amicetose and formation of two novel antitumor tetracenomycins

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Article information

DOI
https://doi.org/10.1039/B417815G
Article type
Communication
Submitted
29 Nov 2004
Accepted
07 Jan 2005
First published
27 Jan 2005

Chem. Commun., 2005, 1604-1606

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Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

M. Pérez, F. Lombó, L. Zhu, M. Gibson, A. F. Braña, J. Rohr, J. A. Salas and C. Méndez, Chem. Commun., 2005, 1604 DOI: 10.1039/B417815G

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