Issue 2, 2005
From the journal:

Chemical Communications

Pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis†

Nourdin Ghalit,a   Dirk T. S. Rijkers,a   Johan Kemmink,a   Cees Versluisb  and  Rob M. J. Liskamp*a  

* Corresponding authors

a Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, Utrecht, The Netherlands
E-mail: R.M.J.Liskamp@pharm.uu.nl
Fax: 31 30 2536655
Tel: 31 30 2537396

b Department of Biomolecular Mass Spectrometry, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands

Abstract

An alkene-bridged mimic of the complex DE-bisthioether-ring system of the antibiotic nisin was prepared in one step from the linear precursor.

Graphical abstract: Pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis

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Article information

DOI
https://doi.org/10.1039/B415555F
Article type
Communication
Submitted
07 Oct 2004
Accepted
10 Nov 2004
First published
02 Dec 2004

Chem. Commun., 2005, 192-194

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Pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis

N. Ghalit, D. T. S. Rijkers, J. Kemmink, C. Versluis and R. M. J. Liskamp, Chem. Commun., 2005, 192 DOI: 10.1039/B415555F

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