Issue 7, 2005

A general method for making bicyclic compounds with nitrogen at a bridgehead—application to the halichlorine spiro subunit

Abstract

N-Protected β-amino aldehydes having the nitrogen in a ring are easily converted into Morita–Baylis–Hillman adducts; O-acetylation and N-deprotection result in spontaneous cyclization to bicyclic structures having nitrogen at a bridgehead.

Graphical abstract: A general method for making bicyclic compounds with nitrogen at a bridgehead—application to the halichlorine spiro subunit

Supplementary files

Article information

Article type
Communication
Submitted
26 Aug 2004
Accepted
07 Oct 2004
First published
23 Dec 2004

Chem. Commun., 2005, 906-908

A general method for making bicyclic compounds with nitrogen at a bridgehead—application to the halichlorine spiro subunit

D. L. J. Clive, M. Yu and Z. Li, Chem. Commun., 2005, 906 DOI: 10.1039/B413481H

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