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Issue 14, 2004
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Possible insights into metal ion recognition in calcium-binding proteins provided by complexing properties of ligands containing amide oxygen donors

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Abstract

The formation constants of the ligand N,N,N′,N′-tetrakis(carbamoylmethyl)-ethylenediamine suggest that the amide oxygen is a stronger Lewis base in water than the alcoholic oxygen, or water, and that part of the selectivity for Ca2+ over Mg2+ shown by calcium-binding proteins such as calmodulin or annexin may be due to the higher affinity of Ca2+ for the O-donor of the Ca-binding amide groups present in such proteins.

Graphical abstract: Possible insights into metal ion recognition in calcium-binding proteins provided by complexing properties of ligands containing amide oxygen donors

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Publication details

The article was received on 22 Mar 2004, accepted on 11 May 2004 and first published on 08 Jun 2004


Article type: Communication
DOI: 10.1039/B404316M
Citation: Chem. Commun., 2004,0, 1632-1633
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    Possible insights into metal ion recognition in calcium-binding proteins provided by complexing properties of ligands containing amide oxygen donors

    C. J. Siddons and R. D. Hancock, Chem. Commun., 2004, 0, 1632
    DOI: 10.1039/B404316M

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