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Issue 19, 2003
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Rapid screening by MALDI-TOF mass spectrometry to probe binding specificity at enzyme active sites

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Abstract

The binding affinity of aspartate decarboxylase has been probed using MALDI-TOF spectrometry; adducts formed covalently in the active site were detected by MALDI-TOF mass spectrometry after incubation of the enzyme with a range of potential ligands in the presence of NaCNBH3; this has highighted key structural features which will aid design of potential inhibitors.

Graphical abstract: Rapid screening by MALDI-TOF mass spectrometry to probe binding specificity at enzyme active sites

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Publication details

The article was received on 16 Jul 2003, accepted on 18 Aug 2003 and first published on 01 Sep 2003


Article type: Communication
DOI: 10.1039/B308182F
Citation: Chem. Commun., 2003, 2416-2417
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    Rapid screening by MALDI-TOF mass spectrometry to probe binding specificity at enzyme active sites

    M. E. Webb, E. Stephens, A. G. Smith and C. Abell, Chem. Commun., 2003, 2416
    DOI: 10.1039/B308182F

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