Issue 10, 2003
From the journal:

Chemical Communications

Unwinding of DNA polymerases by the antitumor drug, cis-diamminedichloroplatinum(ii)

Erika Volckova,a   Ferenc Evanics,a   Wei W. Yanga  and  Rathindra N. Bose*a  

* Corresponding authors

a Department of Chemistry and School of Biomedical Sciences, Kent State University, Kent, OH, 44242, United States
E-mail: rbose@kent.edu
Fax: +1 330 672 3816
Tel: +1 330 672 2851

Abstract

The helix-turn-helix motifs of the DNA binding domains of human polymerase-α and polymerase-κ are dramatically perturbed upon binding to cisplatin with concomitant release of zinc.

Graphical abstract: Unwinding of DNA polymerases by the antitumor drug, cis-diamminedichloroplatinum(ii)

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Article information

DOI
https://doi.org/10.1039/B301356A
Article type
Communication
Submitted
04 Feb 2003
Accepted
20 Mar 2003
First published
16 Apr 2003

Chem. Commun., 2003, 1128-1129

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Unwinding of DNA polymerases by the antitumor drug, cis-diamminedichloroplatinum(II)

E. Volckova, F. Evanics, W. W. Yang and R. N. Bose, Chem. Commun., 2003, 1128 DOI: 10.1039/B301356A

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