Issue 5, 2003
From the journal:

Chemical Communications

A novel concept to activate enediynes for DNA cleavage

Michael Schmittel,*a   Giampietro Viola,b   Francesco Dall’Acquab  and  Guido Morbacha  

* Corresponding authors

a FB 8–OC1 (Chemie-Biologie), Universität Siegen, Adolf-Reichwein-Str, D-57068 Siegen, Germany
E-mail: schmittel@chemie.uni-siegen.de
Fax: +49 271 740 3270
Tel: +49 271 740 4356

b Department of Pharmaceutical Sciences, University of Padova, 35131 Padova, Italy

Abstract

A novel concept is presented to activate enediynes via a biscumulenic intermediate using photoinduced electron transfer (PET).

Graphical abstract: A novel concept to activate enediynes for DNA cleavage

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Article information

DOI
https://doi.org/10.1039/B211783E
Article type
Communication
Submitted
28 Nov 2002
Accepted
28 Jan 2003
First published
11 Feb 2003

Chem. Commun., 2003, 646-647

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A novel concept to activate enediynes for DNA cleavage

M. Schmittel, G. Viola, F. Dall’Acqua and G. Morbach, Chem. Commun., 2003, 646 DOI: 10.1039/B211783E

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