Issue 1, 2003
From the journal:

Chemical Communications

Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride

Hua Fu,*a   Bo Hana  and  Yu-Fen Zhaoa  

* Corresponding authors

a Bioorganic Phosphorus Chemistry Lab of Education Ministry, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, P. R. China
E-mail: fuhua@mail.tsinghua.edu.cn
Fax: 86 10 6278 1695
Tel: 86 10 6277 2259

Abstract

Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride in pyridine produced adenosine 5′-phosphoramidates in good yields under mild conditions, it is interesting that nucleophilic attack of amino acid methyl esters only occurred on α-phosphorus of ADP.

Graphical abstract: Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride

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Article information

DOI
https://doi.org/10.1039/B207992E
Article type
Communication
Submitted
15 Aug 2002
Accepted
22 Nov 2002
First published
02 Dec 2002

Chem. Commun., 2003, 134-135

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Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride

H. Fu, B. Han and Y. Zhao, Chem. Commun., 2003, 134 DOI: 10.1039/B207992E

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