Issue 15, 2002

Synthesis of taurospongin A: a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using π-allyltricarbonyliron lactone complexes

Abstract

The synthesis of taurospongin A has been achieved using, as a key step, a π-allyltricarbonyliron lactone complex to control a highly stereoselective addition of a methyl group to a carbonyl unit located in the side chain of the complex.

Graphical abstract: Synthesis of taurospongin A: a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using π-allyltricarbonyliron lactone complexes

Article information

Article type
Communication
Submitted
22 May 2002
Accepted
05 Jun 2002
First published
01 Jul 2002

Chem. Commun., 2002, 1624-1625

Synthesis of taurospongin A: a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using π-allyltricarbonyliron lactone complexes

C. J. Hollowood, S. V. Ley and S. Yamanoi, Chem. Commun., 2002, 1624 DOI: 10.1039/B204994P

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