Issue 15, 2002
From the journal:

Chemical Communications

Isoserine-based biotinylated photoaffinity probes that interact with penicillin-binding protein 1b†

Thomas Rühl,a   Daniela Volke,a   Katherina Stembera,a   Yasumaru Hatanaka,b   Horst Hennig,c   Frank Schumerc  and  Peter Welzel*a  

* Corresponding authors

a Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, Leipzig, Germany
E-mail: welzel@organik.chemie.uni-leipzig.de
Fax: (+49) (0) 341 9736 599

b Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Japan

c Institut für Anorganische Chemie, Universität Leipzig, Johannisallee 29, Leipzig, Germany

Abstract

The photolytic decomposition of trifunctional carbene generating photoaffinity probes in methanolic solution was studied, a cleavage reaction with butylamine in water, the conjugation with a ligand (moenomycin), and experiments that demonstrate that the fully armed probes interact with penicillin-binding protein 1b.

Graphical abstract: Isoserine-based biotinylated photoaffinity probes that interact with penicillin-binding protein 1b

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Article information

DOI
https://doi.org/10.1039/B204007G
Article type
Communication
Submitted
24 Apr 2002
Accepted
10 Jun 2002
First published
02 Jul 2002

Chem. Commun., 2002, 1630-1631

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Isoserine-based biotinylated photoaffinity probes that interact with penicillin-binding protein 1b

T. Rühl, D. Volke, K. Stembera, Y. Hatanaka, H. Hennig, F. Schumer and P. Welzel, Chem. Commun., 2002, 1630 DOI: 10.1039/B204007G

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