Issue 17, 2001
From the journal:

Chemical Communications

The effect of the primary structure of the polypeptidecatalyst on the enantioselectivity of the Juliá–Colonna asymmetric epoxidation of enones

Paul A. Bentley,a   Robert W. Flood,a   Stanley M. Roberts,*a   John Skidmore,a   Corina B. Smitha  and  John A. Smithb  

* Corresponding authors

a Department of Chemistry, University of Liverpool, Liverpool, UK
E-mail: smrsm@liv.ac.uk

b School of Biological Sciences, University of Liverpool, Liverpool, UK

Abstract

Epoxidation of chalcone (1), using basic hydrogen peroxide, catalysed by polypeptides with defined primary structures demonstrates that the residues in the chain near to the N-terminus determine the stereochemical outcome of the reaction.

Graphical abstract: The effect of the primary structure of the polypeptide catalyst on the enantioselectivity of the Juliá–Colonna asymmetric epoxidation of enones

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Article information

DOI
https://doi.org/10.1039/B104123C
Article type
Communication
Submitted
10 May 2001
Accepted
13 Jul 2001
First published
01 Aug 2001

Chem. Commun., 2001, 1616-1617

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The effect of the primary structure of the polypeptide catalyst on the enantioselectivity of the Juliá–Colonna asymmetric epoxidation of enones

P. A. Bentley, R. W. Flood, S. M. Roberts, J. Skidmore, C. B. Smith and J. A. Smith, Chem. Commun., 2001, 1616 DOI: 10.1039/B104123C

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