Issue 22, 2000
From the journal:

Chemical Communications

Chiral synthesis of the CD ring unit of paclitaxel from d-glucal

Takayuki Momose,a   Masaki Setoguchi,a   Toshiki Fujita,a   Hitoshi Tamuraa  and  Noritaka Chida*a  

* Corresponding authors

a Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku, Yokohama, Japan.
E-mail: chida@applc.keio.ac.jp

Abstract

The chiral synthesis of the fully functionalized CD ring unit of paclitaxel 3 is described; the three component coupling reaction of a cyclohexenone derived from D-glucal by way of Ferrier’s carbocyclization with vinyl cuprate and formaldehyde effectively constructed the carbon framework of 3.

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Article information

DOI
https://doi.org/10.1039/B006170K
Article type
Communication
Submitted
31 Jul 2000
Accepted
05 Oct 2000
First published
31 Oct 2000

Chem. Commun., 2000, 2237-2238

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Chiral synthesis of the CD ring unit of paclitaxel from D-glucal

T. Momose, M. Setoguchi, T. Fujita, H. Tamura and N. Chida, Chem. Commun., 2000, 2237 DOI: 10.1039/B006170K

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