Side chain elongation causes a change from enthalpy driven to entropy driven binding in the molecular recognition of tetraanionic peptides

Xavier Salvatella; Mark W. Peczuh; Margarida Gairí; Rishi K. Jain; Jorge Sánchez-Quesada; Javier de Mendoza; Andrew D. Hamilton; Ernest Giralt

doi:10.1039/B003728L

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Side chain elongation causes a change from enthalpy driven to entropy driven binding in the molecular recognition of tetraanionic peptidesElectronic supplementary information (ESI) available: isothermal titration calorimetry, ¹HNMR and NOE data. See http://www.rsc.org/suppdata/cc/b0/b003728l/

Xavier Salvatella,^a Mark W. Peczuh,^b Margarida Gairí,^c Rishi K. Jain,^b Jorge Sánchez-Quesada,^d Javier de Mendoza,^d Andrew D. Hamilton*^b and Ernest Giralt*^a

Author affiliations

* Corresponding authors

^a Departament de Química Orgànica, Universitat de Barcelona, Martí i Franqués 1-11, 08028, Barcelona, Spain.
E-mail: giralt@qo.ub.es

^b Department of Chemistry, Yale University, New Haven, CT 06520, USA.
E-mail: andrew.hamilton@yale.edu

^c Unitat de Ressonància Magnètica Nuclear, Serveis Científico-Tècnics, Universitat de Barcelona, Martí i Franqués 1-11, 08028, Barcelona, Spain

^d Departamento de Química Orgánica, Universidad Autónoma de Madrid, Cantoblanco, 28049, Madrid, Spain

Abstract

In binding to tetraguanidinium compounds, the average side chain length of tetraanionic peptides determines the thermodynamics of binding, the degree of helix induction and the rigidity of the complex formed.

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Supplementary files

Isothermal titration calorimetry, ¹H NMR and NOE data DOC (86K)

Article information

DOI: https://doi.org/10.1039/B003728L
Article type: Communication
Submitted: 10 May 2000
Accepted: 21 Jun 2000
First published: 07 Jul 2000

Download Citation

Chem. Commun., 2000, 1399-1400

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Side chain elongation causes a change from enthalpy driven to entropy driven binding in the molecular recognition of tetraanionic peptides

X. Salvatella, M. W. Peczuh, M. Gairí, R. K. Jain, J. Sánchez-Quesada, J. de Mendoza, A. D. Hamilton and E. Giralt, Chem. Commun., 2000, 1399 DOI: 10.1039/B003728L

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