Efficient planar chiral 2′-substituted 1,1′-P,N-ferrocene ligands for the asymmetric Heck reaction: control of enantioselectivity and configuration by planar chiral substituent

Wei-Ping Deng; Xue-Long Hou; Li-Xin Dai; Xiao-Wei Dong

doi:10.1039/B003530K

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Efficient planar chiral 2′-substituted 1,1′-P,N-ferrocene

Wei-Ping Deng,^a Xue-Long Hou,*^a Li-Xin Dai^a and Xiao-Wei Dong^a

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* Corresponding authors

^a Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
E-mail: xlhou@pub.sioc.ac.cn

Abstract

Planar chiral 1,1′P,N-2′-substituted 2′ substituted 1,1′-P,N-ferrocene derivatives were efficient ligands for the Pd-catalyzed asymmetric Heck reaction, in which 79–85% yields with high enantioselectivity (80–92%) were obtained within several hours; the enantioselectivity and the absolute configuration were controllable by changing the size of the planar chiral group and/or configuration of planar chirality.

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Article information

DOI: https://doi.org/10.1039/B003530K
Article type: Communication
Submitted: 03 May 2000
Accepted: 20 Jun 2000
First published: 19 Jul 2000

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Chem. Commun., 2000, 1483-1484

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Efficient planar chiral 2′-substituted 1,1′-P,N-ferrocene ligands for the asymmetric Heck reaction: control of enantioselectivity and configuration by planar chiral substituent

W. Deng, X. Hou, L. Dai and X. Dong, Chem. Commun., 2000, 1483 DOI: 10.1039/B003530K

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Efficient planar chiral 2′-substituted 1,1′-P,N-ferrocene

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Efficient planar chiral 2′-substituted 1,1′-P,N-ferrocene ligands for the asymmetric Heck reaction: control of enantioselectivity and configuration by planar chiral substituent

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