A new diastereoselective approach to simplified Dynemicin analogues
Abstract
The stereoselective synthesis of new simplified Dynemicin analogues is reported: key steps of the sequence are the regio- and diastereo-selective functionalization of a quinoline nucleus, bearing a substituent with a stereogenic centre, and the formation of the 10-membered cyclic enediyne system by Pd-catalyzed Stille-like reaction.