CFTA, a new efficient agent for determination of absolute configurations of chiral secondary alcohols
Abstract
The CFTA method using α-cyano-α-fluoro-p-tolylacetic acid (CFTA) can be reliable in assigning absolute configurations of chiral secondary alcohols based on both 1H and 19F NMR spectroscopy, and the most stable and most predominant conformer of the CFTA esters that can explain the 1H and 19F NMR data were supported by X-ray analysis and ab initio calculations.