Photoactivated DNA cleavage via charge transfer promoted N2 release from tris[3-hydroxy-1,2,3-benzotriazine-4(3H)-one]iron(III)

Tucker D. Maurer; Brian J. Kraft; Susan M. Lato; Andrew D. Ellington; Jeffrey M. Zaleski

doi:10.1039/A908005H

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Photoactivated DNA cleavage via charge transfer promoted N₂ release from tris[3-hydroxy-1,2,3-benzotriazine-4(3H)-one]iron(III)

Tucker D. Maurer,^a Brian J. Kraft,^a Susan M. Lato,^a Andrew D. Ellington^b and Jeffrey M. Zaleski*^a

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* Corresponding authors

^a Department of Chemistry and Biochemistry, Indiana University, Bloomington, IN, USA.
E-mail: zaleski@indiana.edu

^b Department of Molecular Biology, University of Texas, Austin, TX, USA

Abstract

Visible wavelength ligand-to-metal (LMCT) activated N₂ release from tris(3-hydroxy-1,2,3-benzotriazine-4(3H)-one]iron(III) produces localized ligand radical intermediates capable of cleaving DNA and represents a new chemical approach to photonuclease design for biological applications.

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Article information

DOI: https://doi.org/10.1039/A908005H
Article type: Communication
Submitted: 05 Oct 1999
Accepted: 18 Nov 1999
First published: 06 Jan 2000

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Chem. Commun., 2000, 69-70

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Photoactivated DNA cleavage via charge transfer promoted N₂ release from tris[3-hydroxy-1,2,3-benzotriazine-4(3H)-one]iron(III)

T. D. Maurer, B. J. Kraft, S. M. Lato, A. D. Ellington and J. M. Zaleski, Chem. Commun., 2000, 69 DOI: 10.1039/A908005H

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Chemical Communications

Photoactivated DNA cleavage via charge transfer promoted N₂ release from tris[3-hydroxy-1,2,3-benzotriazine-4(3H)-one]iron(III)

Abstract

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Photoactivated DNA cleavage via charge transfer promoted N₂ release from tris[3-hydroxy-1,2,3-benzotriazine-4(3H)-one]iron(III)

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