A simple method for the synthesis of 3-substituted and 2,3-disubstituted 4-chlorofurans is described which involves CuCl/bipy-catalysed regioselective cyclisation of 1-acetoxy-2,2,2-trichloroethyl allyl ethers followed successively by dechloroacetoxylation with Zn dust and tandem dehydrohalogenation–aromatisation with ButOK/18-crown-6.
R. N. Ram and I. Charles, Chem. Commun., 1999, 2267 DOI: 10.1039/A907270E
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