New synthesis of pyridoacridines based on an intramolecular aza-Diels–Alder reaction followed by an unprecedented rearrangement†
Abstract
The synthesis of pyridoacridines related to the ascididemins can be performed by an intramolecular aza-Diels–Alder cycloaddition of an α,β-unsaturated hydrazone to a quinone followed by an unprecedented rearrangement to yield benzo- or pyrido-[b]acridine-6,11-diones.