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Issue 8, 1998
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Asymmetric intercalation of N1-(acridin-9-ylcarbonyl)spermine at homopurine sites of duplex DNA

Abstract

N 1 -(Acridin-9-ylcarbonyl)spermine binds at 5′-pu-p-pu..5′-py-p-py sites of DNA with the acridine moiety asymmetrically intercalated, stacked between the two purine bases; the spermine moiety interacts with the homopyrimidine phosphodiester backbone of the intercalation site and protects against DNase I cleavage of this backbone, but does not protect against cleavage of the homopurine backbone at the same intercalation site.

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Article type: Paper
DOI: 10.1039/A709193A
Citation: Chem. Commun., 1998,0, 929-930
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    Asymmetric intercalation of N1-(acridin-9-ylcarbonyl)spermine at homopurine sites of duplex DNA

    I. S. Blagbrough, S. Taylor, S. Taylor, M. L. Carpenter, V. Novoselskiy, T. Shamma and I. S. Haworth, Chem. Commun., 1998, 0, 929
    DOI: 10.1039/A709193A

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