Issue 8, 1997

Biosynthesis of fluoroacetate and 4-fluorothreonine by Streptomyces cattleya. The stereochemical processing of glycerol

Abstract

When both (2R)-[1- 2 H 2 ]- and (2S)-[1- 2 H 2 ]-glycerol are incubated with resting cell suspensions of S. cattleya, only the 2R-enantiomer labels the fluoromethyl groups of fluoroacetate and 4-fluorothreonine, with retention of both deuterium atoms, placing metabolic and mechanistic limitations on the process of biological fluorination.

Article information

Article type
Paper

Chem. Commun., 1997, 799-800

Biosynthesis of fluoroacetate and 4-fluorothreonine by Streptomyces cattleya. The stereochemical processing of glycerol

J. Nieschalk, J. T. G. Hamilton, C. D. Murphy, D. B. Harper and D. O’Hagan, Chem. Commun., 1997, 799 DOI: 10.1039/A700498B

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