A novel hydride rearrangement of the acetal group of tetraacetal tetraoxa-cages mediated by Lewis acids

Abstract

Treatment of tetraoxa-cages 1a–f with Lewis acids such as TiCl ₄ , AlCl ₃ , BF ₃ ·OEt ₂ and MeSO ₃ H in dichloromethane at 25 °C gives the rearrangement products 2a–f in 90% yields regioselectively and stereoselectively; a novel hydride rearrangement of the acetal group of tetraacetal tetraoxa-cages mediated by Lewis acids.