Two-step synthesis of C-glycosyl juglones from unprotected sugars: a novel approach to angucycline antibiotics
Abstract
The two-steps synthesis of C-glycosyl juglones, versatile synthetic intermediates for angucycline antibiotics, has been developed by the C-glycosidation of naphthalene-1,5-diol with an unprotected sugar and the subsequent regioselective photooxygenation of the resultant C-glycosyl naphthalenediol.