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Issue 24, 1995
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Synthesis of enantiomerically pure α-hydroxyaldehydes from the corresponding α-hydroxycarboxylic acids: novel substrates for Escherichia coli transketolase

Abstract

Enantiomerically pure (R)-α-hydroxyaldehydes (>95% ee) are prepared from the corresponding α-hydroxyesters by silyl protection, reduction with diisobutylaluminium hydride, and finally deprotection under acidic conditions; subsequent coupling of these aldehydes with lithium hydroxypyruvate, catalysed by Escherichia coli transketolase, leads to novel optically pure triols.

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Article type: Paper
DOI: 10.1039/C39950002475
Citation: J. Chem. Soc., Chem. Commun., 1995,0, 2475-2476
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    Synthesis of enantiomerically pure α-hydroxyaldehydes from the corresponding α-hydroxycarboxylic acids: novel substrates for Escherichia coli transketolase

    A. J. Humphrey, N. J. Turner, R. McCague and S. J. C. Taylor, J. Chem. Soc., Chem. Commun., 1995, 0, 2475
    DOI: 10.1039/C39950002475

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