Conjugate addition of chloride to α,β-unsaturated chiral imides promoted by BCl3-derivatives. A synthesis of 3-chlorobutanoic acid
Abstract
The conjugate addition of chloride to chiral but-2-enoic imides promoted by BCl3-derivatives proceeds with diastereoisomeric ratios of up to 90 : 10 and affords the corresponding 3-chlorobutanoic imides from which, after mild hydrolysis, the 3-chlorobutanoic acid is obtained.