Direct trifluoromethylthiolation of aryl halides using methyl fluorosulfonyldifluoroacetate and sulfur
Abstract
In the presence of S8 and copper(I) iodide, methyl fluorosulfonyldifluoroacetate 1 reacts with aryl halides 2 in hexamethylphosphoramide (HMPA) or N-methylpyrrolidinone (NMP) at 100–110 °C to give the corresponding trifluoromethylthiolated derivatives 3 in good yields.