A concise, general enantioselective synthetic route to 2(R)- and 2(S)-[1′(S)-azido-2-phenylethyl]oxirane and related epoxides
Abstract
The title oxiranes were constructed in > 95% enantiomeric excess (e.e.) utilizing a Sharpless asymmetric epoxidation followed by regioselective azide displacement with [Ti(OPri)2(N3)2] as the key steps.