A regio-, (E)-stereo-, and chemo-selective synthesis of unsymmetrical divinylmethanols starting from L- and D-tartrates via organocyanocopper Lewis acid mediated 1,3-chirality transfer

Abstract

A regio-, (E)-stereo-, and chemo-selective synthesis of synthetically useful unsymmetrical divinylmethanol derivatives, compounds that are not easily accessible by other means, via an organocyanocopper·BF₃ mediated 1,3-chirality transfer in mixed solvents involving tetrahydrofuran at –78 °C is reported.