Synthesis of 4,6-dideoxy-4-formamido-α-D-mannose containing tri-, tetra-, and penta-saccharides, antigenic determinants of the Brucella A and M antigens

Abstract

A synthetic strategy based upon the use of thioglycosides to generate 1,2-trans-glycosidic linkages has been developed and has permitted efficient synthesis of pentameric α-1,2 linked 4,6-dideoxy-4-formamido-α-D-mannose homo-oligomers as well as structures containing α-1,3 linkages.